This article is an invitation to discuss a recurrent question in the field of Humanities: “Does it make any sense to talk about Humanities in the age of generative AI?”. While many papers have been devoted to this topic, this paper brings together three distinct disciplinary viewpoints, namely the humanities, computer science, and education, to examine it from complementary angles. It discusses labor market transformations, ethical issues related to authorship and plagiarism, cultural bias, as well as the effects of AI on students' cognitive processes and learning practices. It also considers how these issues are being reshaped in current expert discussions. From these three perspectives, the analysis suggests that profound changes and transformations are inevitable, and the Humanities are no exception. In this context, it becomes necessary to distinguish between those tasks that cannot be replaced by artificial intelligence and those that are likely to be progressively taken over by it.